Django is an open source server-side web application framework, written in Python
TurboGears, another open source MVC-style Web application framework based on Python.
"Web2py may be young but the mailing list has 2000 messages month which is similar to django and far more than turbogears"
from question "Web2py in the future?"
"Compare the very active django tag on stack overflow with that of pylons or turbogears though and i d argue getting started is simply easier with django irrespective of anything to do with code"
from question "Architecting from scratch in Python: what to use?"