Gio
GIO is striving to provide a modern, easy-to-use VFS API that sits at the right level in the library stack, as well as other generally useful APIs for desktop applications (such as networking and D-Bus support)
Pygobject
GTK+ and other GObject bindings are provided by PyGObject through introspection.
Others
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Pygobject is nothing more than a thin layer of glue making gobject gio . from question Displaying images in a py2exe'd PyGTK program |