MyISAM is a non-transactional storage engine for MySQL
TokuDB is a storage engine for MySQL that is designed for high performance on write-intensive workloads while providing high compression and schema flexibility.
"From my personal use i experienced about 5 - 10 times less disk usage due to tokudb s compression and it s much much faster than myisam or innodb"
from question "Storage engine for large amounts of constantly inserted data which should be available instantly"
"At the beginning the insert performance of innodb is almost 50 times slower than myisam and tokudb is 40 times slower than myisam"
from question "Why TokuDB and InnoDB insert is so slow compared to MyISAM"