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Pygtk

PyGTK is the Python binding for the GTK+ widget library.

Wxpython

WxPython is a Python wrapper for the cross-platform C++ GUI API wxWidgets.



Others

Example

Also pygtk is lighter than wxpython but i ended up bitting the bullet and using wxpython for the same purpose recently it is heavy but it didn t have any affect on the script performance

from question  

Display an image as a splash screen when running Windows batch file, vbscript/wscript or Python console script

Thanks to opencv i managed to rewrite everything with wxpython which i know better than pygtk

from question  

Python GStreamer webcam viewer

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