PyGTK is the Python binding for the GTK+ widget library.
WxPython is a Python wrapper for the cross-platform C++ GUI API wxWidgets.
"Thanks to opencv i managed to rewrite everything with wxpython which i know better than pygtk"
from question "Python GStreamer webcam viewer"
"Also pygtk is lighter than wxpython but i ended up bitting the bullet and using wxpython for the same purpose recently it is heavy but it didn t have any affect on the script performance"
from question "Display an image as a splash screen when running Windows batch file, vbscript/wscript or Python console script"