PyQt is a set of Python v2 and v3 bindings for The Qt Company's Qt application framework and runs on all platforms supported by Qt including Windows, macOS, Linux, iOS and Android
WxPython is a Python wrapper for the cross-platform C++ GUI API wxWidgets.
"Wxpython is probably easier than pyqt or tkinter i don t want to start a framework war"
from question "How to create a GUI table in which the users can input data in Python?"
"Two words of warning against wxpython it is not possible to install it via the popular fink package manager on mac os x currently which makes it far less portable than pyqt and tkinter"
from question "Python GUI for portable app"